Botox is the household name of injectables. But these days, a few new names are joining the wrinkle-smoothing party: Daxxify and Xeomin. If you’ve heard of them, you might be wondering… do they all do the same thing? And if not, which one is best for you?
The good news? They all work. The even better news? Each one has its own benefits and best-case uses depending on your goals, your timeline, and your lifestyle.
Botox:
We can’t talk wrinkle relaxers without starting with Botox. It’s the one most people know and trust, and for good reason. It’s been around for decades, has tons of research behind it, and works really well for smoothing forehead lines, crow’s feet, and frown lines between the brows.
Why people love it:
- Reliable and consistent results
- Usually kicks in within 3–5 days
- Results last around 3–4 months
If you’re newer to injectables or just want that tried-and-true smoothness, Botox is a solid choice.
Daxxify:
Daxxify is the newest player on the scene and it’s shaking things up with its longer-lasting formula. The major difference? Daxxify is peptide-powered. It doesn’t use human serum albumin (which Botox and Xeomin both contain), and that change may be why it sticks around a little longer.
But beyond just the longevity, Daxxify is becoming a go-to option for treating deeper lines , especially in areas where muscles are stronger and tend to move more often, like:
- Frown lines (aka “11s” between the brows)
- Deeper forehead creases
- Neck bands (when used off-label)
- Strong glabellar muscles
Because of its concentrated and pure formula, it’s especially helpful for people who feel like they “burn through” Botox faster or want to stay smooth longer without touch-ups.
Why people love it:
- Can last 6–9 months (almost double the usual!)
- Great for deeper, more stubborn lines
- Ideal if you want fewer appointments or have a busy schedule
“Daxxify is a more concentrated and more pure formula, which makes it ideal for deeper, more aggressive lines. And because of how it’s formulated, it often lasts longer , which my patients love.”
Diane Howard, RN and Daxxify Phoenix Injector
If you’re managing more pronounced wrinkles or just over doing touch-ups every few months, Daxxify is probably your new fave.
Xeomin:
Xeomin markets itself as the purest version of a wrinkle relaxer. It contains only the active botulinum toxin, with no accessory proteins. This “naked injectable” is designed to reduce the risk of building up resistance over time, which can happen with repeated Botox use (though it’s rare).
It performs similarly to Botox and is great for treating classic expression lines, like:
- Crow’s feet
- Horizontal forehead lines
- Soft frown lines
Why people love it:
- No additives or unnecessary proteins
- May lower risk of resistance
- Works similarly to Botox in onset and duration
“Unlike Daxxify, which is designed for longevity, Xeomin is all about simplicity. It’s a more minimalist option with no added proteins, which is great for people looking for a clean formula that still delivers great results.”
— Diane Howard, RN and Xeomin Scottsdale Specialist
If you’re into clean beauty or want a more minimalist option, Xeomin fits the vibe.
Table of Contents
How to Choose:
Ready to try out a new wrinkle treatment? Choosing the right one depends on a few things:
- Your goals: Want to stay frozen longer? Daxxify. Prefer subtle and classic? Botox. Into cleaner ingredients? Xeomin.
- Your routine: If you’re low-maintenance or travel often, Daxxify’s longer results could be worth it. If you like predictable touch-ups and have a fave injector, Botox or Xeomin may suit you best.
- Your body: Some people metabolize wrinkle relaxers faster than others. Your injector can help you find what works best for your unique body chemistry.
Final Thoughts:
Botox, Daxxify, and Xeomin all deliver smoother skin, softened lines, and that refreshed, lifted look, but they each bring something a little different to the table. Think of them as tools in your beauty kit, not competitors.
So whether you’re team OG, team long-lasting, or team clean, your wrinkle-smoothing game is covered. The best part? You don’t have to pick alone. A good injector will walk you through your options and help you decide what fits your vibe and vision best.
Because at the end of the day, it’s not about chasing trends. It’s about picking what makes you look and feel like your favorite version of you.